ING4 polyclonal (C-term), anti-human
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In stock
SKU
AC-AP20568a
Catalog Number: AC-AP20568a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB47839
Applications: IHC-P, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB47839
Applications: IHC-P, WB
Datasheet
Request Information
Background:
Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1).
Other Names:
Inhibitor of growth protein 4, p29ING4, ING4
Target/Specificity:
This ING4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 162-195 amino acids from the C-terminal region of human ING4.
Antigen Type: Synthetic Peptide
Gene Name: ING4
Gene ID: 51147
Primary Accession: Q9UNL4
Other Accession: Q9D8Y8; Q8WYH8; Q8C0D7; Q5ZKY4; Q3T095
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1).
Other Names:
Inhibitor of growth protein 4, p29ING4, ING4
Target/Specificity:
This ING4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 162-195 amino acids from the C-terminal region of human ING4.
Antigen Type: Synthetic Peptide
Gene Name: ING4
Gene ID: 51147
Primary Accession: Q9UNL4
Other Accession: Q9D8Y8; Q8WYH8; Q8C0D7; Q5ZKY4; Q3T095
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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