INHBA polyclonal (N-term), anti-human
€0.00
In stock
SKU
AC-AP11126a
Catalog Number: AC-AP11126a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB20703
Applications: WB, IHC-P, IF, FC
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB20703
Applications: WB, IHC-P, IF, FC
Datasheet
Request Information
Background:
The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome.
Other Names:
Inhibin beta A chain, Activin beta-A chain, Erythroid differentiation protein, EDF, INHBA
Target/Specificity:
This INHBA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-112 amino acids from the N-terminal region of human INHBA.
Antigen Region:
85-112
Antigen Type: Synthetic Peptide
Gene Name: INHBA
Gene ID: 3624
Primary Accession: P08476
NCBI Accession: NP_002183.1
Other Accession: P18331; Q04998; P07995; NP_002183.1; P55102; P43032
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome.
Other Names:
Inhibin beta A chain, Activin beta-A chain, Erythroid differentiation protein, EDF, INHBA
Target/Specificity:
This INHBA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-112 amino acids from the N-terminal region of human INHBA.
Antigen Region:
85-112
Antigen Type: Synthetic Peptide
Gene Name: INHBA
Gene ID: 3624
Primary Accession: P08476
NCBI Accession: NP_002183.1
Other Accession: P18331; Q04998; P07995; NP_002183.1; P55102; P43032
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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