INHBB Polyclonal Antibody

Background:
The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.

Research Area: Cancer, Neuroscience, Signal transduction

Synonyms:
Activin beta B chain, Activin beta-B chain, INHBB, INHBB, Inhibin beta 2, Inhibin beta B chain, Inhibin beta B subunit

Immunogen: Synthetic peptide of human INHBB

Swissprot: P09529
Gene Accession: NP_002184

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.8 mg/mL
Dilution: IHC 1:30-150, ELISA 1:2000-10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-6307/sc-6306/sc-50287