INHBB polyclonal (C-term), anti-human, mouse
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In stock
SKU
AC-AP11131b
Catalog Number: AC-AP11131b
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB23814
Applications: IHC-P, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB23814
Applications: IHC-P, WB
Datasheet
Request Information
Background:
The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.
Other Names:
Inhibin beta B chain, Activin beta-B chain, INHBB
Target/Specificity:
This INHBB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 369-397 amino acids from the C-terminal region of human INHBB.
Antigen Region:
369-397
Antigen Type: Synthetic Peptide
Gene Name: INHBB
Gene ID: 3625
Primary Accession: P09529
NCBI Accession: NP_002184.2
Other Accession: P17491; P04088; Q04999; P27093; P42917; NP_002184.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.
Other Names:
Inhibin beta B chain, Activin beta-B chain, INHBB
Target/Specificity:
This INHBB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 369-397 amino acids from the C-terminal region of human INHBB.
Antigen Region:
369-397
Antigen Type: Synthetic Peptide
Gene Name: INHBB
Gene ID: 3625
Primary Accession: P09529
NCBI Accession: NP_002184.2
Other Accession: P17491; P04088; Q04999; P27093; P42917; NP_002184.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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