iNOS polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Nitric oxide synthase, inducible is an enzyme that in humans is encoded by the NOS2 gene. Nitric oxide(NO) is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter; it is implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. Three different NOS isoforms have been identified which fall into two distinct types, constitutive and inducible. The inducible NOS(iNOS) isoform is expressed in a variety of cell types and tissues in response to inflammatory agents and cytokines. The human iNOS(NOS2) gene is approximately 37 kb in length and consists of 26 exons and 25 introns. Diefenbach et al.(1999) studied the relationship of IL12 and nitric oxide synthase-2(NOS2) to innate immunity to the parasite Leishmania in mice. And conclude that NOS2-derived NO is a prerequisite for cytokine signaling and function in innate immunity. From studies in Tanzania and Kenya, Hobbs et al.(2002) identified a novel single-nucleotide polymorphism, -1173C-T(163730.0001), in the NOS2 promoter that was significantly associated with protection from symptomatic malaria and severe malarial anemia.

Description:
Rabbit IgG polyclonal antibody for Nitric oxide synthase, inducible (NOS2) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
HEP NOS antibody, HEP-NOS antibody, Hepatocyte NOS antibody, HEPNOS antibody, inducible antibody, Inducible nitric oxide synthase antibody, Inducible NO synthase antibody, Inducible NOS antibody, INOS antibody, Inosl antibody, MAC NOS antibody, Macrophage NOS antibody, Nitric oxide synthase 2 inducible antibody, Nitric oxide synthase 2 inducible macrophage antibody, Nitric oxide synthase 2A(inducible hepatocytes) antibody, Nitric oxide synthase antibody, Nitric oxide synthase inducible antibody, NOS 2 antibody, NOS 2A antibody, NOS antibody, Nos II antibody, NOS type II antibody, Nos2 antibody, NOS2_HUMAN antibody, NOS2A antibody, Peptidyl-cysteine S-nitrosylase NOS2 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human iNOS(1110-1124aa VEDYFFQLKSQKRYH), identical to the related rat and mouse sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Reactivity: human, mouse, rat. No cross reactivity with other proteins.

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.