INPPL1 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
INPPL1(Inositol polyphosphate phosphatase-like 1), also called SHIP2, encodes inositol polyphosphate-5 phosphatase-like 1, a protein that in addition to the phosphatase domain contains an SH2(src-homology domain 2) motif. INPPL1 is a member of the family of inositol triphosphate phosphatases. The INPPL1 gene is mapped on 11q13.4. Immunoblot analysis revealed that SHIP2 was widely expressed in fibroblast and nonhematopoietic tumor cell lines, unlike the SHIP protein, which was found only in cell lines of hematopoietic origin. Using human epithelial cell lines and primary human corneal and epidermal keratinocytes, Yu et al.(2008) showed that microRNA-184(MIR184) interfered with the ability of MIR205 to downregulate expression of SHIP2.SHIP2 may play a significant role in regulation of phosphatidylinositol 3-prime-kinase signaling by growth factors and insulin. By targeting the translation-initiating ATG codon and deleting the first 18 exons encoding Inppl1, Sleeman et al.(2005) generated Inppl1 -/- mice that were null for Inppl1 mRNA and protein.

Description:
Rabbit IgG polyclonal antibody for Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (INPPL1) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
4 antibody, 5-trisphosphate 5-phosphatase 2 antibody, 51C protein antibody, EC 3.1.3.n1 antibody, inositol polyphosphate phosphatase like 1 antibody, Inositol polyphosphate phosphatase like protein 1 antibody, Inositol polyphosphate phosphatase-like protein 1 antibody, INPPL-1 antibody, INPPL1 antibody, Phosphatidylinositol 3 antibody, Phosphatidylinositol 3,4,5 trisphosphate 5 phosphatase 2 antibody, Protein 51C antibody, SH2 domain containing inositol 5' phosphatase 2 antibody, SH2 domain-containing inositol 5''-phosphatase 2 antibody, SH2 domain-containing inositol phosphatase 2 antibody, SHIP-2 antibody, SHIP2 antibody, SHIP2_HUMAN antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence in the middle region of human INPPL1(349-363aa QRDSQEDWTTFTHDR), identical to the related rat and mouse sequences.A synthetic peptide corresponding to a sequence in the middle region of human INPPL1(349-363aa QRDSQEDWTTFTHDR), identical to the related rat and mouse sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.