Insig1 polyclonal, anti-human, mouse, rat, hamster, bovine antibody
€320.00
In stock
SKU
AC-ABV10665-100
Catalog Number: AC-ABV10665-100
Size: 100 µg
Host: Rabbit IgG
Applications: WB
Datasheet
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Size: 100 µg
Host: Rabbit IgG
Applications: WB
Datasheet
Request Information
Background:
Insulin-induced gene (InSig) localizes in the endoplasmic recticulum(ER) and is highly expressed in the liver and fibroblast cell lines. InSig1 and InSig2 play important roles in the regulation of cholesterol biosynthesis. Sterol induces InSig1 binding to the sterol-sensing domain of SREBP cleavage-activating protein (SCAP). Both InSig1 and Insig2 prevent the export of SCAP from the ER and thus, inhibit cholesterol synthesis by preventing the proteolytic cleavage of SREBPs by the Golgi enzymes.
Other Names:
CL-6 , INSIG1 , MGC1405
Primary Accession: Q08755
Other Accession: NP_071787
Gene Name: Insig1
Gene ID: 64194
Concentration (mg/ml): 0.5 mg/ml
Insulin-induced gene (InSig) localizes in the endoplasmic recticulum(ER) and is highly expressed in the liver and fibroblast cell lines. InSig1 and InSig2 play important roles in the regulation of cholesterol biosynthesis. Sterol induces InSig1 binding to the sterol-sensing domain of SREBP cleavage-activating protein (SCAP). Both InSig1 and Insig2 prevent the export of SCAP from the ER and thus, inhibit cholesterol synthesis by preventing the proteolytic cleavage of SREBPs by the Golgi enzymes.
Other Names:
CL-6 , INSIG1 , MGC1405
Primary Accession: Q08755
Other Accession: NP_071787
Gene Name: Insig1
Gene ID: 64194
Concentration (mg/ml): 0.5 mg/ml
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