Insulin protease polyclonal, anti-human, mouse, rat, zebrafish

Background:
Insulin degrading enzyme (IDE), also known as insulinase, insulin protease or insulysin, cleaves the peptide hormone insulin with consequences for insulin response and resistance. IDE is a highly conserved thiol metalloprotease with ubiquitous expression including the brain. Since its discovery, IDE has been shown to degrade a variety of bioactive peptides. Recently the finding that IDE clears intracellular and extracellular amyloid products has spurred research into the link between IDE function and human neurodegenerative disease such as Alzheimer’s.

Alternative Name:
Insulinase, IDE, Abeta-degrading protease, FLJ35968, Ide, IDE, Insulin protease, Insulin-degrading enzyme, Insulinase, Insulysin, OTTHUMP00000020097,

Application Dilution:
WB:1:1,000-1:2,000
IHC:1:50-1:200

Specificity: Insulin protease polyclonal antibody detects endogenous levels of Insulin protease protein.

Immunogen:
recombinant protein

MW: 118 kDa

Swiss-Prot: P14735(Human) Q9JHR7(Mouse) P35559(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.