Insulin Receptor (phospho-Y1355) polyclonal, anti-human
€328.00
In stock
SKU
BS4270
Background:
The insulin receptor (IR) is a heterodimeric protein complex that has an intracellular β subunit and an extracellular α subunit, which is disulfide- linked to a transmembrane segment. The insulin ligand binds to the IR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to IR induces phosphorylation of intracellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin.
Alternative Name:
Insulin receptor, IR, CD220, INSR
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: p-Insulin Receptor (Y1355) polyclonal antibody detects endogenous levels of Insulin Receptor protein only when phosphorylated at Tyr1355.
Immunogen:
Synthetic phosphopeptide derived from human Insulin Receptor around the phosphorylation site of Tyrosine 1355.
MW: ~ 156 kDa
Swis Prot.: P06213
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The insulin receptor (IR) is a heterodimeric protein complex that has an intracellular β subunit and an extracellular α subunit, which is disulfide- linked to a transmembrane segment. The insulin ligand binds to the IR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to IR induces phosphorylation of intracellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin.
Alternative Name:
Insulin receptor, IR, CD220, INSR
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: p-Insulin Receptor (Y1355) polyclonal antibody detects endogenous levels of Insulin Receptor protein only when phosphorylated at Tyr1355.
Immunogen:
Synthetic phosphopeptide derived from human Insulin Receptor around the phosphorylation site of Tyrosine 1355.
MW: ~ 156 kDa
Swis Prot.: P06213
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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