Insulin Receptor Polyclonal Antibody

Background:
This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.

Research Area: Cancer, Cardiovascular, Metabolism, Neuroscience, Signal Transduction

Synonyms:
CD220, HHF5, INSR

Immunogen: A synthetic peptide of human Insulin Receptor (NP_000199.2).

Swissprot: P06213
Gene ID: 3643

Calculated MW: 155 kDa/156 kDa
Observed MW: 180 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.