Integrin alpha 6A (clone 1A10), anti-human
€564.00
In stock
SKU
ARP-21-5184
Catalog Number: 21-5184
Size: 100 µg
Isotype: Mouse IgG1
Size: 100 µg
Isotype: Mouse IgG1
Background:
Integrins are a family of heterodimeric membrane glycoproteins consisting of non-covalently associated alpha and beta subunits. More than 18 alpha and 8 beta subunits with numerous splice variant isoforms have been identified in mammals. In general, integrins function as receptors for extracellular matrix proteins. Certain integrins can also bind to soluble ligands or to counter-receptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), resulting in aggregation of cells. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migRation and apoptosis. For integrin subunits alpha3 and alpha6, two cytoplasmic variants, A and B, have been identified.
Clone: 1A10
Isotype: Mouse IgG1
Source: 1A10 is a Mouse monoclonal IgG1, k antibody derived by fusion of SP2/0 Mouse myeloma cells with spleen cells from a BALB/c Mouse immunized with a synthetic peptide corresponding to the C-terminal 28 amino acids of integrin alpha6A including an appending N-terminal cysteine (CKKDHYDATYH-KAEIHAQPSDKERLTSDA) coupled to keyhole limpet hemocyanin.
Reactivity: human. A broad species reactivity is expected because of the conserved nature of the epitope.
Specificity: 1A10 reacts exclusively the cytoplasmic domain of non-phosphorylated integrin subunit alpha6A. 1A10 stains the basement membrane zone of skin, myoepithelial cells in sweat glands, peripheral nerves, sebaceous glands and some blood vessels in the dermis.
Form: Each vial contains 100ul purified monoclonal antibody in PBS containing 0.09% sodium azide.
Applications: Immunocytochemistry, Immunohistochemistry (frozen), Western blotting
Storage: Store at 4C, or in small aliquots at -20C.
Integrins are a family of heterodimeric membrane glycoproteins consisting of non-covalently associated alpha and beta subunits. More than 18 alpha and 8 beta subunits with numerous splice variant isoforms have been identified in mammals. In general, integrins function as receptors for extracellular matrix proteins. Certain integrins can also bind to soluble ligands or to counter-receptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), resulting in aggregation of cells. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migRation and apoptosis. For integrin subunits alpha3 and alpha6, two cytoplasmic variants, A and B, have been identified.
Clone: 1A10
Isotype: Mouse IgG1
Source: 1A10 is a Mouse monoclonal IgG1, k antibody derived by fusion of SP2/0 Mouse myeloma cells with spleen cells from a BALB/c Mouse immunized with a synthetic peptide corresponding to the C-terminal 28 amino acids of integrin alpha6A including an appending N-terminal cysteine (CKKDHYDATYH-KAEIHAQPSDKERLTSDA) coupled to keyhole limpet hemocyanin.
Reactivity: human. A broad species reactivity is expected because of the conserved nature of the epitope.
Specificity: 1A10 reacts exclusively the cytoplasmic domain of non-phosphorylated integrin subunit alpha6A. 1A10 stains the basement membrane zone of skin, myoepithelial cells in sweat glands, peripheral nerves, sebaceous glands and some blood vessels in the dermis.
Form: Each vial contains 100ul purified monoclonal antibody in PBS containing 0.09% sodium azide.
Applications: Immunocytochemistry, Immunohistochemistry (frozen), Western blotting
Storage: Store at 4C, or in small aliquots at -20C.
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