Integrin β4 (phospho Tyr1510) Polyclonal Antibody

Background:
integrin subunit beta 4(ITGB4) Homo sapiens Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Alternative Names:
ITGB4, Integrin beta-4, GP150, CD antigen CD104

Immunogen: The antiserum was produced against synthesized peptide derived from human ITGB4 around the phosphorylation site of Tyr1510. AA range:1481-1530

Isotype: Rabbit

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml

Observed band: 202

GeneID: ITGB4

Storage: -20°C/1 year

NOTE: For Research Use Only