Integrin β4 polyclonal, anti-human, mouse

Background:
Integrins are heterodimers composed of noncovalently associated transmembrane a and b subunits. The 16 a and 8 b subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, collagen and vitronectin. Certain integrins can also bind to soluble ligands, such as fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Integrin β4 (ITGB4), also known as CD104, is a 1,822 amino acid single-pass type I membrane protein belonging to the Integrin β chain family. Known to associate with Integrin α6, Integrin β4 functions as a receptor for Laminin and is predominantly expressed by epithelia. Integrin β4 exists as five alternatively spliced isoforms that are encoded by a gene located on human chromosome 17q25.1.

Alternative Name:
ITGB4, CD 104, CD104, CD104 antigen, gp150, Integrin beta 4 subunit, Integrin beta-4, ITB4, ITG B4, ITGB 4, Itgb4,

Application Dilution:
WB:1:1,000-1:2,000
IHC:1:50-1:200

Specificity: Integrin β4 polyclonal antibody detects endogenous levels of Integrin β4 protein.

Immunogen:
recombinant protein

MW: 210 kDa

Swiss-Prot: P16144 (Human) A2A863(Mouse)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.