Interleukin-1 beta (IL-1beta) (clone HIL1-NR5), anti-human

Background:
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.

Decription:
Mouse monoclonal Antibody to human IL-1beta

Synonyms: IL-1B, IL1-BETA, IL1F2

Clone: HIL1-NR5

Isotype: Mouse IgG2b

Immunogen: Recombinant human IL-1?

Reactivity: human

Specificity: Human IL-1beta. No cross reactivity with murine IL-1beta was detected

Form: Affinity Purified, in PBS containing 0.1% Sodium Azide

Applications: ELISA

Working Dilution: In direct ELISA, 1:106 dilution

Storage: 2-8C for immediate use; or at -20C (aliquot) Avoid freeze-thaw cycles