Interleukin-1 beta (IL1 beta) polyclonal, anti-rat

Quantity: 100 µg

Background:
Interleukin-1beta (IL-1beta) is a potent stimulator of bone resorption whose gene is mapped to 2q14, and has been implicated in the pathogenesis of high bone turnover and osteoporosis. IL-1beta, a prominent microglia-derived cytokine, caused oligodendrocyte death in coculture with astrocytes and microglia, but not in pure culture of oligodendrocytes alone. It also can cause nuclear export of a specific NCOR corepressor complex, resulting in derepression of a specific subset of nuclear factor-kappa-B (NFKB)-regulated genes. Furthermore, Microenvironmental IL-1beta and, to a lesser extent, IL-1alpha are required for in vivo angiogenesis and invasiveness of different tumor cells. Additional, the cooperation of IL-1beta and PDGFB induces contractile-to-synthetic phenotype modulation of human aortic smooth muscle cells in culture. Moreover, the association with disease may be explained by the biologic properties of IL-1beta, which is an important proinflammatory cytokine and a powerful inhibitor of gastric acid secretion.

Description:
Rabbit IgG polyclonal antibody for Interleukin-1 beta (IL1B) detection. Tested with WB, ELISA in Rat.

Synonyms:
Catabolin antibody, H1 antibody, Hematopoietin 1 antibody, IFN beta inducing factor antibody, IL 1 antibody, IL 1 beta antibody, IL 1B antibody, IL-1 beta antibody, IL1 BETA antibody, IL1B antibody, IL1B_HUMAN antibody, IL1F2 antibody, Interleukin 1 beta antibody, Interleukin 1 beta precursor antibody, Interleukin-1 beta antibody, LAF antibody, OAF antibody, Osteoclast activating factor antibody, OTTHUMP00000162031 antibody, Preinterleukin 1 beta antibody, Preinterleukin beta antibody, Pro interleukin 1 beta antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived rat IL1 beta recombinant protein (Position: V117-S268). Rat IL1 beta shares 78% and 90% amino acid (aa) sequences identity with human and mouse IL1 beta, respectively.E.coli-derived rat IL1 beta recombinant protein (Position: V117-S268). Rat IL1 beta shares 78% and 90% amino acid (aa) sequences identity with human and mouse IL1 beta, respectively.

Form: Lyophilized; Each vial contains 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: rat

Applications: WB, ELISA

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.