Interleukin-17 (IL17) polyclonal, anti-mouse

Quantity: 100 µg

Background:
IL-17(Interleukin-17), originally identified as a transcript from a rodent T-cell hybridoma by Rouvier et al. in 1993, is the founding member of a group of cytokines called the IL-17 family. Known as CTLA8 in rodents, IL-17 shows high homology to viral IL-17 encoded by an open reading frame of the T-lymphotropic rhadinovirus Herpesvirus saimiri. Mouse IL-17 shares 85% amino acid sequence homology with rat. Interleukin 17 is a cytokine that acts as a potent mediator in delayed-type reactions by increasing chemokine production in various tissues to recruit monocytes and neutrophils to the site of inflammation, similar to Interferon gamma. IL-17 is produced by T-helper cells and is induced by IL–23 which results in destructive tissue damage in delayed-type reactions. Interleukin 17 as a family functions as a proinflammatory cytokine that responds to the invasion of the immune system by extracellular pathogens and induces destruction of the pathogen's cellular matrix. Interleukin 17 acts synergistically with tumor necrosis factor and interleukin-1. To elicit its functions, IL-17 binds to a type I cell surface receptor called IL-17R of which there are at least three variants IL17RA, IL17RB, and IL17RC.

Description:
Rabbit IgG polyclonal antibody for Interleukin-17A (IL17A) detection. Tested with WB, ELISA in Mouse.

Synonyms:
CTLA 8 antibody, CTLA-8 antibody, CTLA8 antibody, Cytotoxic T lymphocyte associated antigen 8 antibody, Cytotoxic T lymphocyte associated protein 8 antibody, Cytotoxic T lymphocyte associated serine esterase 8 antibody, Cytotoxic T-lymphocyte-associated antigen 8 antibody, IL 17A antibody, IL-17 antibody, IL-17A antibody, IL17 antibody, IL17A antibody, Interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8) antibody, Interleukin 17A antibody, Interleukin-17A antibody, Interleukin17 antibodyInter, leukin17A antibody, OTTHUMP00000016597 antibody, OTTMUSP00000046003 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E. coli-derived mouse IL-17 recombinant protein(Position: A26-A158).E. coli-derived mouse IL-17 recombinant protein(Position: A26-A158).

Form: Lyophilized; Each vial contains 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: mouse

Applications: WB, ELISA

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.