Interleukin-18 (IL18) polyclonal, anti-human

Quantity: 100 µg

Background:
Interleukin-18 also known as IL18 is a protein which in humans is encoded by the IL18 gene. The protein encoded by this gene is a proinflammatory cytokine.IL-18 is a cytokine produced by macrophages and other cells that belongs to the IL-1 superfamily. IL-18 works by binding to the interleukin-18 receptor, and together with IL-12 it induces cell-mediated immunity following infection with microbial products like lipopolysaccharide(LPS). After stimulation with IL-18, natural killer(NK) cells and certain T cells release another important cytokine called interferon-gamma(IFN-gamma) or type II interferon that plays an important role in activating the macrophages or other cells.The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production in B cells. IL-18 binding protein(IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. The human interleukin 18 gene IL18 maps to 11q22.2-q22.3, closely linked to the DRD2 gene locus and distinct from mapped IDDM loci.

Description:
Rabbit IgG polyclonal antibody for Interleukin-18 (IL18) detection. Tested with WB in Human.

Synonyms:
Iboctadekin antibody, IFN gamma inducing factor antibody, IFN-gamma-inducing factor antibody, IGIF antibody, IL 1 gamma antibody, IL 18 antibody, IL 1g antibody, IL-1 gamma antibody, IL-18 antibody, IL1 gamma antibody, IL18 antibody, IL18 protein antibody, IL1F4 antibody, IL1g antibody, IL1gamma antibody, ILIF4 antibody, Interferon gamma inducing factor antibody, Interferon gamma-inducing factor antibody, Interleukin 1 gamma antibody, Interleukin 18 antibody, Interleukin-1 gamma antibody, Interleukin-18 antibody, Interleukin18 antibody, MGC12320 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of Human IL18(175-193aa KKEDELGDRSIMFTVQNED).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.