Interleukin-23 p19 (IL-23 p19) polyclonal, anti-human, mouse

Quantity: 100 µl

Description:
IL-23p19 associates with IL-12b to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 binds to an heterodimeric receptor complex composed of IL-12RB1 and IL-23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Synonyms:
Interleukin-23 Subunit p19, Interleukin-23 Subunit alpha, IL-23-A

Isotype: Rabbit Polyclonal

Immunogen:
Recombinant mouse IL-23p19.

Form: Purified, in 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.

Specificity:
Recognizes mouse IL-23p19. Detects a band of ~23kDa by Western blot. Cross-reacts with human IL-23p19. Does not cross-react with human IL23p40.

Reactivity: human, mouse

Applications: ELISA, Western Blot

Working DIlution: Optimal conditions must be determined individually for each application.

Storage: 2-8C immediate use, or -20C (aliquoted)