Interleukin-32 (IL-32) (clone AT2F9), anti-human

Decription:
The gene encoding IL32 is located on human chromosome 16p13.3 and is organized into eight exons. IL32 is mainly expressed in natural killer cells, T cells, epithelial cells, and blood monocytes. It can induce the proinflammatory cytokines TNFalpha and IL1beta in murine peritoneal macrophages as well as in phorbol ester-differentiated human THP1 cells. In the inflamed lesions of chronic pancreas, the ductal expression of IL32 was markedly increased. Pancreatic duct cells are the local source of IL32, and IL32 may play an important role in inflammatory responses and pancreatic cancer growth. Recently, a synergism between IL32 and other well characterized players in innate immunity has been documented.

Synonyms: Interleukin 32 isoform A, IL-32, Natural killer cells protein 4(NK4), Tumor necrosis factor alpha-inducing factor (TAIF), Interleukin 32, Interleukin 32 isoform A IL 32alpha, IL 32beta, IL 32delta, IL 32gamma, Interleukin 32, Natural killer cells protein 4, NK 4, NK4, TAIF, TAIFa, TAIFb, TAIFc, TAIFd, il32

Clone: AT2F9. Anti-human IL32 mAb, clone AT2F9, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human IL32 protein.

Isotype: Mouse IgG1, k

Immunogen: Recombinant human IL32 (1-131aa) purified from E. coli

Reactivity: human

Form: Purified, in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide

Applications: ELISA, WB

Working Dilution: Optimal dilution should be performed by user.

NCBI Nr.: NP_001012651

Concentration: 0.1 mg/ml

Storage: Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.

References:
Nishida A, et al. (2009) J Biol Chem, 284(26):17868-76.
Kobayashi H, et al. (2009) Cytokine, 46(3):351-8.
Mabilleau G, et al. (2009) PLoS One, 4(1):e4173.