Internexin α polyclonal, anti-human, mouse, rat

Background:
Alpha-internexin is a brain specific type IV intermediate filament protein. This axonal protein is found in most, if not all, neurons of the CNS. The head domain of alpha-internexin is essential for self-assembly into a filament network. Expression levels of alpha-internexin have been shown to be maximal during late embryogenesis and to decline into adulthood, suggesting that this protein plays a role in regulatory processes during the development of the brain. The alpha-internexin promoter has been shown to be activated by Brn-3a or Brn-3c transcription factor binding, while Brn-3b binding to the promoter results in alpha-internexin repression.

Alternative Name:
Alpha-Inx, NF-66, Neurofilament-66, INA, NEF5, 66 kDa neurofilament protein, AINX, Alpha Inx, Alpha-internexin, Alpha-Inx, INA, Internexin neuronal intermediate filament protein alpha, MGC12702, NEF 5, NEF5, Neurofilament 5 (66kD), Neurofilament 5, Neurofilament 66, Neurofilament 66 tax binding protein, Neurofilament-66, NF 66, NF-66, NF66, TXBP 1, TXBP1,

Application Dilution:
WB:1:1,000-1:5,000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100

Specificity: Internexin α polyclonal antibody detects endogenous levels of Internexin α protein.

Immunogen:
Recombinant protein

MW: 66 kDa

Swiss-Prot: Q16352(Human) P46660(Mouse) P23565(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.