INTS4 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS8145
Background:
RNA polymerase II (Pol II) is an enzyme that is composed of twelve subunits and is responsible for the transcription of protein-coding genes. Transcription initiation requires Pol II-mediated recruitment of transcription machinery to a target promoter, thereby allowing transcription to begin. The integrator complex is a multi-protein complex that associates with the C-terminal domain of Pol II and is involved in small nuclear RNA (snRNA) transcription and 3’-end processing. INTS4 (Integrator complex subunit 4) is a 963 amino acid protein that contains eight HEAT repeats and is a component of the integrator complex. Localized to the nucleus, INTS4 plays a role in the processing of select snRNAs and mediates snRNA transcriptional regulation events. Four isoforms of INTS4 are expressed due to alternative splicing events.
Alternative Name:
Integrator complex subunit 4, Int4, INTS4, MSTP093
Application Dilution: WB: 1:500 - 1:2000
Specificity: INTS4 polyclonal antibody detects endogenous levels of INTS4 protein.
Immunogen:
Recombinant full length Human INTS4.
MW: ~ 108 kDa
Swis Prot.: Q96HW7
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
RNA polymerase II (Pol II) is an enzyme that is composed of twelve subunits and is responsible for the transcription of protein-coding genes. Transcription initiation requires Pol II-mediated recruitment of transcription machinery to a target promoter, thereby allowing transcription to begin. The integrator complex is a multi-protein complex that associates with the C-terminal domain of Pol II and is involved in small nuclear RNA (snRNA) transcription and 3’-end processing. INTS4 (Integrator complex subunit 4) is a 963 amino acid protein that contains eight HEAT repeats and is a component of the integrator complex. Localized to the nucleus, INTS4 plays a role in the processing of select snRNAs and mediates snRNA transcriptional regulation events. Four isoforms of INTS4 are expressed due to alternative splicing events.
Alternative Name:
Integrator complex subunit 4, Int4, INTS4, MSTP093
Application Dilution: WB: 1:500 - 1:2000
Specificity: INTS4 polyclonal antibody detects endogenous levels of INTS4 protein.
Immunogen:
Recombinant full length Human INTS4.
MW: ~ 108 kDa
Swis Prot.: Q96HW7
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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