Involucrin polyclonal, anti-human, rat

Background:
Involucrin is a precursor protein of the keratinocyte cornified envelope, which is formed beneath the inner surface of the cell membrane during terminal differentiation. During keratinocyte terminal differentiation, glutamine residues of involucrin become covalently cross-linked to other envelope precursors via covalent epsilon-(gamma-glutamyl) lysine bonds. Moreover, its large size allows involucrin to cross-link molecules that are separated by substantial distances in the cornified envelope. These properties allow a single involucrin molecule to form multiple cross-links, in multiple spatial planes, with other envelope precursors.

Alternative Name:
IVL, INVO, Involucrin, IVL,

Application Dilution:
WB:1:500-1:2,000
IHC:1:50-1:200
FC:1:50-1:200

Specificity: Involucrin polyclonal antibody detects endogenous levels of Involucrin protein.

Immunogen:
Recombinant protein

MW: 120 kDa

Swiss-Prot: P07476(Human) P48998(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.