Ionotropic Glutamate receptor 2 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
GLUR2, also called Glutamate receptors and mediated by a G-protein that inhibits adenylate cyclase activity, sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazolpropionate(AMPA), are ligand-activated cation channels that mediate the fast component of excitatory postsynaptic currents in neurons of the central nervous system. GLUR2's cytogenetic location is 4q32.1. The crystal structures of the GLUR2 ligand-binding core in the apo state and in the presence of the antagonist DNQX, the partial agonist kainate, and the full agonists AMPA and glutamate. As previously demonstrated in rats, the GLUR2 in human has RNA editing, posttranscriptional change of the sequence at the mRNA level. And interruption of the interaction between C-terminal Glur2 and PDZ domain-containing proteins, such as GRIP and PICK1, resulted in increased AMPA receptor-mediated excitatory transmission and blockade of long-term depression.GLUR2 plays a major role in depression at synapses in which glutamate remains in the synaptic cleft for prolonged periods of time during normal operation of the synapse.

Description:
Rabbit IgG polyclonal antibody for Glutamate receptor 2 (GRIA2) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
AMPA 2 antibody, AMPA selective glutamate receptor 2 antibody, AMPA-selective glutamate receptor 2 antibody, AMPA2 antibody, Glu R2 antibody, Glu RB antibody, GluA2 antibody, GluR 2 antibody, GluR B antibody, GluR B flop antibody, GluR K2 antibody, GluR-2 antibody, GluR-B antibody, GluR-K2 antibody, GLUR2 antibody, GluRB antibody, Glutamate receptor 2 antibody, Glutamate receptor ionotropic AMPA 2 antibody, Glutamate receptor ionotropic AMPA2 antibody, Glutamate receptor ionotropic antibody, Gria 2 antibody, Gria2 antibody, GRIA2_HUMAN antibody, HBGR 2 antibody, HBGR2 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence in the middle region of human Ionotropic Glutamate receptor 2(260-277aa FQIVDYDDSLVSKFIERW), identical to the related rat and mouse sequences.A synthetic peptide corresponding to a sequence in the middle region of human Ionotropic Glutamate receptor 2(260-277aa FQIVDYDDSLVSKFIERW), identical to the related rat and mouse sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.