IP3 receptor polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Inositol 1,4,5-trisphosphate receptor type 1, also known as IP3R or IP3R1, is a protein that in humans is encoded by the ITPR1 gene. It is mapped to 3p26.1. The product of the ITPR1 gene is predominantly enriched in cerebellar Purkinje cells but is also concentrated in neurons in the hippocampal CA1 region, caudate-putamen, and cerebral cortex. The ITPR1 gene encodes the inositol 1,4,5-triphosphate(IP3) receptor, an intracellular IP3-gated calcium channel that modulates intracellular calcium signaling. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in ITPR1 cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. This gene has been shown to interact with CA8, PRKG1, FKBP1A and so on.

Description:
Rabbit IgG polyclonal antibody for Inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
4 antibody, 5-trisphosphate receptor antibody, 5-trisphosphate receptor type 1 antibody, DKFZp313E1334 antibody, DKFZp313N1434 antibody, inositol 1 4 5 triphosphate receptor type 1 antibody, Inositol 1 4 5 trisphosphate Receptor Type 1 antibody, Inositol 1 antibody, Inositol 145-trisphosphate Receptor Type 1 antibody, InsP3R1 antibody, IP3 antibody, IP3 receptor antibody, IP3 receptor isoform 1 antibody, IP3R 1 antibody,, IP3R antibodyIP3R1 antibody,, ITPR 1 antibody, Itpr1 antibody, SCA15 antibody, SCA16 antibody, SCA29 antibody, Type 1 inositol 1 4 5 trisphosphate receptor antibody, Type 1 inositol 1 antibody, Type 1 InsP3 receptor antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human IP3 receptor(1913-1927aa TTQITEEVRDQLLEA), identical to the related rat and mouse sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.