IPO11 polyclonal (N-term), anti-human
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In stock
SKU
AC-AP8772a
Catalog Number: AC-AP8772a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB23487
Applications: FC, IHC-P, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB23487
Applications: FC, IHC-P, WB
Datasheet
Request Information
Background:
IPO11 functions in nuclear protein import as nuclear transport receptor. It serves as receptor for nuclear localization signals (NLS) in cargo substrates and is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). It mediates the nuclear import of UBE2E3, and of RPL12 (By similarity).
Other Names:
Importin-11, Imp11, Ran-binding protein 11, RanBP11, IPO11, RANBP11
Target/Specificity:
This IPO11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-85 amino acids from the N-terminal region of human IPO11.
Antigen Region:
56-85
Antigen Type: Synthetic Peptide
Gene Name: IPO11
Gene ID: 51194
Primary Accession: Q9UI26
NCBI Accession: NP_001128251.1;NP_057422.3
Other Accession: Q8K2V6
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
IPO11 functions in nuclear protein import as nuclear transport receptor. It serves as receptor for nuclear localization signals (NLS) in cargo substrates and is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). It mediates the nuclear import of UBE2E3, and of RPL12 (By similarity).
Other Names:
Importin-11, Imp11, Ran-binding protein 11, RanBP11, IPO11, RANBP11
Target/Specificity:
This IPO11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-85 amino acids from the N-terminal region of human IPO11.
Antigen Region:
56-85
Antigen Type: Synthetic Peptide
Gene Name: IPO11
Gene ID: 51194
Primary Accession: Q9UI26
NCBI Accession: NP_001128251.1;NP_057422.3
Other Accession: Q8K2V6
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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