IPO4 Polyclonal Antibody

Background:
Importin-4is aproteinthat in humans is encoded by theIPO4gene. Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Signal Transduction

Synonyms:
Imp4, Imp4b, Importin 4, Importin 4b, Importin-4, Importin-4b, Ipo4, IPO4, Ran binding protein 4, Ran-binding protein 4, RanBP4

Immunogen: Recombinant protein of human IPO4

Swissprot: Q8TEX9
Gene Accession: BC003690

Calculated MW: 119 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.2 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-55280/sc-55283/sc-292402