IPO7 Polyclonal Antibody

Background:
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Signal transduction

Synonyms:
FLJ14581, Imp 7, Imp7, Importin-7, Importin7, IPO 7, IPO7, IPO7, MGC138673, Ran binding protein 7, Ran-binding protein 7, RANBP 7, RanBP7

Immunogen: Synthetic peptide of human IPO7

Swissprot: O95373
Gene Accession: NP_006382

Calculated MW: 120 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.5 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:100-1:300

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-55230/sc-55231/sc-55235/sc-134913