IPO8 Polyclonal Antibody

Background:
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Research Area: Epigenetics and Nuclear Signaling, Signal transduction

Synonyms:
FLJ26580, Imp 8, Imp8, Importin-8, Importin8, IPO 8, IPO8, IPO8, Ran binding protein 8, RAN BP8, Ran-binding protein 8, RANBP 8, RanBP8

Immunogen: Synthetic peptide of human IPO8

Swissprot: O15397
Gene Accession: NP_006381

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 1.2 mg/mL
Dilution: IHC 1:100-1:300

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-74668