IQGAP3 Polyclonal Antibody

Background:
IQGAP3 (IQ motif containing GTPase activating protein 3) is a 1,631 amino acid protein that acts as an effector of Cdc42 and Rac 1, linking their activation to the cytoskeleton during neuronal morphogenesis. A novel member of the IQGAP family, IQGAP3 is highly expressed in brain where it localizes to axons of hippocampal neurons. IQGAP3 contains one Ras-GAP domain, a CH (calponin-homology) domain, four IQ domains and is encoded by a gene located on human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.

Research Area: Neuroscience, Signal Transduction

Synonyms:
IQ motif containing GTPase activating protein 3, IQGA3, IQGAP 3, IQGAP3, MGC10170, MGC10831, MGC1947, OTTHUMP00000031854, OTTHUMP00000031855, Ras GTPase activating like protein IQGAP3, Ras GTPase-activating-like protein IQGAP3

Immunogen: Recombinant protein of human IQGAP3

Swissprot: Q86VI3
Gene Accession: BC131536

Calculated MW: 185 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.3 mg/mL
Dilution: WB 1:200-1:1000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-162958/sc-162960