IRAK1 (phospho-T209) polyclonal, anti-human, mouse
€328.00
In stock
SKU
BS4698
Background:
Three structurally related ligands for IL-1Rs have been described. These include two agonists, IL-1α and IL-1β, and a specific receptor antagonist, IL-1Rα. Two distinct receptors designated IL-1RI and IL-1RII have been identified, each of which belong to the Ig superfamily. The preponderance of evidence suggests IL-1RI to be the functional IL-1 receptor. Binding of IL-1 to its cognate receptor results in the activation of the NFκB signaling pathway. The IL-1-dependent kinase termed IRAK (for IL-1 receptor-associated kinase) co-immunoprecipitates with activated IL-1RI and has been implicated as an upstream mediator of NFκB activation. Additional support for this assertion comes from the fact that a related Drosophila protein, Pelle, is a known upstream activator of Dorsal, the Drosophila homolog of NFκB.
Alternative Name:
Interleukin-1 receptor-associated kinase 1, IRAK-1, IRAK1, IRAK
Application Dilution: WB: 1:500~1:1000
Specificity: p-IRAK1 (T209) polyclonal antibody detects endogenous levels of IRAK1 protein only when phosphorylated at Thr209.
Immunogen:
Synthetic phosphopeptide derived from human IRAK1 around the phosphorylation site of Threonine 209.
MW: ~ 76 kDa
Swis Prot.: P51617
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Three structurally related ligands for IL-1Rs have been described. These include two agonists, IL-1α and IL-1β, and a specific receptor antagonist, IL-1Rα. Two distinct receptors designated IL-1RI and IL-1RII have been identified, each of which belong to the Ig superfamily. The preponderance of evidence suggests IL-1RI to be the functional IL-1 receptor. Binding of IL-1 to its cognate receptor results in the activation of the NFκB signaling pathway. The IL-1-dependent kinase termed IRAK (for IL-1 receptor-associated kinase) co-immunoprecipitates with activated IL-1RI and has been implicated as an upstream mediator of NFκB activation. Additional support for this assertion comes from the fact that a related Drosophila protein, Pelle, is a known upstream activator of Dorsal, the Drosophila homolog of NFκB.
Alternative Name:
Interleukin-1 receptor-associated kinase 1, IRAK-1, IRAK1, IRAK
Application Dilution: WB: 1:500~1:1000
Specificity: p-IRAK1 (T209) polyclonal antibody detects endogenous levels of IRAK1 protein only when phosphorylated at Thr209.
Immunogen:
Synthetic phosphopeptide derived from human IRAK1 around the phosphorylation site of Threonine 209.
MW: ~ 76 kDa
Swis Prot.: P51617
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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