IRAK4 polyclonal, anti-human

Background:
Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1.

Synonyms: IRAK-4, Renal carcinoma antigen NY-REN-64, Interleukin-1 receptor-associated kinase 4

Cellular Location: Cytoplasm

Immunogen:
A synthetic peptide of human IRAK4

Gene Symbol: IRAK4

Gene ID: 51135

Swiss prot: Q9NWZ3

Calculated MW: 52kDa

Recommended dilution:
WB 1:500-2000, IHC 1:25-100,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.