IRAK4 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS7963
Background:
Interleukin-1 receptor (IL1R)-associated kinases (IRAKs) are important mediators in the signal transduction of Toll-like receptor (TLR) and IL1R family members, collectively referred to as TIRs. IRAK family members include two active kinases, IRAK-1 and IRAK-4, and two inactive kinase, IRAK-2 and IRAK-M. Binding of IL-1 to its cognate receptor results in the activation of the NFkB signaling pathway and MAP kinase pathways. IRAK-4 appears to act upstream of other IRAKs and phosphorylates IRAK-1 on threonine 387. It is highly expressed in liver and kidney tissues, but also displays a wide, low level of expression in other tissues. IRAK-4 is an essential component of innate immunity. Deficiency of IRAK-4 leads to recurrent bacterial infections and profound hyporesponsiveness to LPS and IL-1. Therefore, IRAK-4 may be a potential target for therapeutic drug design.
Alternative Name:
IL-1 receptor-associated kinase 4, Interleukin 1 receptor associated kinase 4 mutant form 1, Interleukin-1 receptor-associated kinase 4, Interleukin1 receptor associated kinase 4, IPD1, IRAK 4, IRAK-4, IRAK4, IRAK4 mutated form 1, IRAK4_HUMAN, LOC 51135, NY REN 64, NY REN 64 antigen, NY-REN-64, REN64, Renal carcinoma antigen NY-REN-64,
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: IRAK4 polyclonal antibody detects endogenous levels of IRAK4 protein.
Immunogen:
Recombinant full length Human IRAK4.
MW: ~ 52 kDa
Swis Prot.: Q9NWZ3
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Interleukin-1 receptor (IL1R)-associated kinases (IRAKs) are important mediators in the signal transduction of Toll-like receptor (TLR) and IL1R family members, collectively referred to as TIRs. IRAK family members include two active kinases, IRAK-1 and IRAK-4, and two inactive kinase, IRAK-2 and IRAK-M. Binding of IL-1 to its cognate receptor results in the activation of the NFkB signaling pathway and MAP kinase pathways. IRAK-4 appears to act upstream of other IRAKs and phosphorylates IRAK-1 on threonine 387. It is highly expressed in liver and kidney tissues, but also displays a wide, low level of expression in other tissues. IRAK-4 is an essential component of innate immunity. Deficiency of IRAK-4 leads to recurrent bacterial infections and profound hyporesponsiveness to LPS and IL-1. Therefore, IRAK-4 may be a potential target for therapeutic drug design.
Alternative Name:
IL-1 receptor-associated kinase 4, Interleukin 1 receptor associated kinase 4 mutant form 1, Interleukin-1 receptor-associated kinase 4, Interleukin1 receptor associated kinase 4, IPD1, IRAK 4, IRAK-4, IRAK4, IRAK4 mutated form 1, IRAK4_HUMAN, LOC 51135, NY REN 64, NY REN 64 antigen, NY-REN-64, REN64, Renal carcinoma antigen NY-REN-64,
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: IRAK4 polyclonal antibody detects endogenous levels of IRAK4 protein.
Immunogen:
Recombinant full length Human IRAK4.
MW: ~ 52 kDa
Swis Prot.: Q9NWZ3
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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