IRF8 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Interferon regulatory factor 8(IRF8) also known as Interferon consensus sequence-binding protein(ICSBP), is a protein that in humans is encoded by the IRF8 gene. By genomic sequence analysis, the IRF8 gene is mapped to chromosome 16q24.1. Interferon consensus sequence-binding protein(ICSBP) is a transcription factor of the interferon(IFN) regulatory factor(IRF) family. The IRF family proteins bind to the IFN-stimulated response element(ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. IRF8 is a transcription factor that plays critical roles in the regulation of lineage commitment and in myeloid cell maturation including the decision for a common myeloid progenitor(CMP) to differentiate into a monocyte precursor cell.

Description:
Rabbit IgG polyclonal antibody for Interferon regulatory factor 8 (IRF8) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
H ICSBP antibody, H-ICSBP antibody, HGNC:5358 antibody, HGNC5358 antibody, HICSBP antibody, ICSBP 1 antibody, ICSBP antibody, ICSBP1 antibody, Interferon Consensus Sequence Binding Protein 1 antibody, Interferon consensus sequence binding protein antibody, Interferon consensus sequence-binding protein antibody, Interferon Regulatory Factor 8 antibody, IRF 8 antibody, IRF-8 antibody, IRF8 antibody, IRF8_HUMAN antibody, MYLS antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human IRF8(411-426aa ASHQRSFFRENQQITV), different from the related mouse and rat sequences by two amino acids.A synthetic peptide corresponding to a sequence at the C-terminus of human IRF8(411-426aa ASHQRSFFRENQQITV), different from the related mouse and rat sequences by two amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.