IRF9 Polyclonal Antibody

Background:
Interferon regulatory factor 9is aproteinthat in humans is encoded by theIRF9gene, previously known as ISGF3G. Transcription regulatory factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.

Research Area: Epigenetics and Nuclear Signaling, Immunology

Synonyms:
IFN alpha responsive transcription factor subunit, IFN-alpha-responsive transcription factor subunit, Interferon regulatory factor 9, interferon stimulated transcription factor 3, Interferon-stimulated gene factor 3 gamma, interferon-stimulated transcription factor 3, gamma 48kDa, IRF 9, IRF-9, Irf9, IRF9, ISGF 3 gamma, ISGF-3 gamma, ISGF3, ISGF3 p48 subunit, ISGF3G, OTTHUMP00000164692, OTTHUMP00000164693, p48, Transcriptional regulator ISGF3 subunit gamma

Immunogen: Recombinant protein of human IRF9

Swissprot: Q00978
Gene Accession: BC035716

Calculated MW: 44 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.6 mg/mL
Dilution: WB 1:200-1:1000, IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-496/sc-10793