ISCU Polyclonal Antibody

Background:
This gene encodes a component of the iron-sulfur (Fe-S) cluster scaffold. Fe-S clusters are cofactors that play a role in the function of a diverse set of enzymes, including those that regulate metabolism, iron homeostasis, and oxidative stress response. Alternative splicing results in transcript variants encoding different protein isoforms that localize either to the cytosol or to the mitochondrion. Mutations in this gene have been found in patients with hereditary myopathy with lactic acidosis. A disease-associated mutation in an intron may activate a cryptic splice site, resulting in the production of a splice variant encoding a putatively non-functional protein. A pseudogene of this gene is present on chromosome 1.

Research Area: Metabolism, Signal transduction

Synonyms:
2310020H20Rik, HML, hnifU, Iron sulfur cluster assembly enzyme ISCU mitochondrial, Iron sulfur cluster scaffold homolog (E. coli), Iron sulfur cluster scaffold homolog, Iron-sulfur cluster assembly enzyme ISCU, Iscu, IscU iron sulfur cluster scaffold homolog, ISCU, ISU2, MGC74517, mitochondrial, NIFU, NifU like N terminal domain containing, NifU like N terminal domain containing protein, NifU like protein, NifU-like N-terminal domain-containing protein, NifU-like protein, NIFUN, Nitrogen fixation cluster like, OTTHUMP00000238760, OTTHUMP00000238761, OTTHUMP00000238762, OTTHUMP00000238764, OTTHUMP00000238765

Immunogen: Fusion protein of human ISCU

Swissprot: Q9H1K1
Gene Accession: BC011906

Calculated MW: 18 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.96 mg/mL
Dilution: WB 1:500-1:2000, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.