ITCH Antibody (Center) Blocking peptide
€363.00
In stock
SKU
AC-BP13626c
Background:
Atrophin-1 contains a polyglutamine repeat, expansion ofwhich is responsible for dentatorubral and pallidoluysian atrophy.The protein encoded by this gene interacts with atrophin-1. Thisencoded protein is a closely related member of the NEDD4-likeprotein family. This family of proteins are E3 ubiquitin-ligasemolecules and regulate key trafficking decisions, includingtargeting of proteins to proteosomes or lysosomes. This encodedprotein contains four tandem WW domains and a HECT (homologous tothe E6-associated protein carboxyl terminus) domain. It can act asa transcriptional corepressor of p45/NFE2 and may participate inthe regulation of immune responses by modifying Notch-mediatedsignaling. It is highly similar to the mouse Itch protein, whichhas been implicated in the regulation and differentiation oferythroid and lymphoid cells.
Other Names:
E3 ubiquitin-protein ligase Itchy homolog, Itch, 632-, Atrophin-1-interacting protein 4, AIP4, NFE2-associated polypeptide 1, NAPP1, ITCH
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13626c was selected from the Center region of ITCH. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: ITCH
Gene ID: 83737
Primary Accession: Q96J02
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Atrophin-1 contains a polyglutamine repeat, expansion ofwhich is responsible for dentatorubral and pallidoluysian atrophy.The protein encoded by this gene interacts with atrophin-1. Thisencoded protein is a closely related member of the NEDD4-likeprotein family. This family of proteins are E3 ubiquitin-ligasemolecules and regulate key trafficking decisions, includingtargeting of proteins to proteosomes or lysosomes. This encodedprotein contains four tandem WW domains and a HECT (homologous tothe E6-associated protein carboxyl terminus) domain. It can act asa transcriptional corepressor of p45/NFE2 and may participate inthe regulation of immune responses by modifying Notch-mediatedsignaling. It is highly similar to the mouse Itch protein, whichhas been implicated in the regulation and differentiation oferythroid and lymphoid cells.
Other Names:
E3 ubiquitin-protein ligase Itchy homolog, Itch, 632-, Atrophin-1-interacting protein 4, AIP4, NFE2-associated polypeptide 1, NAPP1, ITCH
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13626c was selected from the Center region of ITCH. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: ITCH
Gene ID: 83737
Primary Accession: Q96J02
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
| Is Featured? | No |
|---|
Write Your Own Review