ITCH polyclonal (Center), anti-mouse
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In stock
SKU
AC-AP13626C
Catalog Number: AC-AP13626C
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB33154
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB33154
Applications: WB
Datasheet
Request Information
Background:
Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells.
Other Names:
E3 ubiquitin-protein ligase Itchy homolog, Itch, 632-, Atrophin-1-interacting protein 4, AIP4, NFE2-associated polypeptide 1, NAPP1, ITCH
Target/Specificity:
This ITCH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 509-536 amino acids from the Central region of human ITCH.
Antigen Region:
509-536
Antigen Type: Synthetic Peptide
Gene Name: ITCH
Gene ID: 83737
Primary Accession: Q96J02
NCBI Accession: NP_001244066.1;NP_001244067.1;NP_113671.3
Other Accession: Q8C863; NP_113671.3
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells.
Other Names:
E3 ubiquitin-protein ligase Itchy homolog, Itch, 632-, Atrophin-1-interacting protein 4, AIP4, NFE2-associated polypeptide 1, NAPP1, ITCH
Target/Specificity:
This ITCH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 509-536 amino acids from the Central region of human ITCH.
Antigen Region:
509-536
Antigen Type: Synthetic Peptide
Gene Name: ITCH
Gene ID: 83737
Primary Accession: Q96J02
NCBI Accession: NP_001244066.1;NP_001244067.1;NP_113671.3
Other Accession: Q8C863; NP_113671.3
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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