ITGA2 Polyclonal Antibody

Background:
This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants.

Research Area: Cancer, Metabolism, Signal Transduction

Synonyms:
BR, CD 49b, CD49 antigen like family member B, CD49 antigen-like family member B, CD49b, CD49b antigen, Collagen receptor, DX5, Glycoprotein Ia deficiency included, GP Ia, GP Ia deficiency, included, GPIa, HPA 5 included, HPA5 included, Human platelet alloantigen system 5, Integrin alpha 2, Integrin alpha II, Integrin alpha-2, Integrin, alpha 2 (CD49B alpha 2 subunit of VLA 2 receptor), ITA2, ITGA2, Platelet alloantigen Br(a), included, Platelet antigen Br, Platelet glycoprotein GPIa, Platelet glycoprotein Ia, Platelet glycoprotein Ia/IIa, Platelet membrane glycoprotein Ia, Platelet receptor for collagen, deficiency of, included, Very late activation protein 2 receptor alpha 2 subunit, VLA 2 alpha chain, VLA 2, VLA 2 subunit alpha, VLA-2 subunit alpha, VLA2, VLA2 receptor alpha 2 subunit, VLAA2

Immunogen: Synthetic peptide of human ITGA2

Swissprot: P17301
Gene Accession: NP_002194

Calculated MW: 129 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.4 mg/mL
Dilution: WB 1:200-1:1000, IHC 1:25-1:100

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-6586/sc-9089

Citation(s):
https://journals.sagepub.com/doi/abs/10.1177/1535370218791797