ITGA2B Polyclonal Antibody

Background:
This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia.

Research Area: Cancer, Cardiovascular, Immunology, Signal Transduction, Stem Cells

Synonyms:
ITGA2B, BDPLT16, BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GTA, HPA3, PPP1R93

Immunogen: Recombinant fusion protein of human ITGA2B (NP_000410.2).

Swissprot: P08514
Gene ID: 3674

Calculated MW: 103 kDa/109 kDa/113 kDa
Observed MW: 135 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IF 1:10-1:100"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.