ITGA4 Polyclonal Antibody

Background:
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants.

Research Area: Cancer, Cardiovascular, Immunology, Signal Transduction, Stem Cells

Synonyms:
ITGA4, CD49D, IA4

Immunogen: A synthetic peptide of human ITGA4 (NP_000876.3).

Swissprot: P13612
Gene ID: 3676

Calculated MW: 21 kDa/114 kDa
Observed MW: 80 kDa/130 kDa/160 kDa/170 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.