ITGAL Antibody (Center) Blocking peptide
€363.00
In stock
SKU
AC-BP13692c
Background:
ITGAL encodes the integrin alpha L chain. Integrins areheterodimeric integral membrane proteins composed of an alpha chainand a beta chain. This I-domain containing alpha integrin combineswith the beta 2 chain (ITGB2) to form the integrin lymphocytefunction-associated antigen-1 (LFA-1), which is expressed on allleukocytes. LFA-1 plays a central role in leukocyte intercellularadhesion through interactions with its ligands, ICAMs 1-3(intercellular adhesion molecules 1 through 3), and also functionsin lymphocyte costimulatory signaling. Two transcript variantsencoding different isoforms have been found for this gene.
Other Names:
Integrin alpha-L, CD11 antigen-like family member A, Leukocyte adhesion glycoprotein LFA-1 alpha chain, LFA-1A, Leukocyte function-associated molecule 1 alpha chain, CD11a, ITGAL, CD11A
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13692c was selected from the Center region of ITGAL. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: ITGAL (HGNC:6148)
Gene ID: 3683
Primary Accession: P20701
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
ITGAL encodes the integrin alpha L chain. Integrins areheterodimeric integral membrane proteins composed of an alpha chainand a beta chain. This I-domain containing alpha integrin combineswith the beta 2 chain (ITGB2) to form the integrin lymphocytefunction-associated antigen-1 (LFA-1), which is expressed on allleukocytes. LFA-1 plays a central role in leukocyte intercellularadhesion through interactions with its ligands, ICAMs 1-3(intercellular adhesion molecules 1 through 3), and also functionsin lymphocyte costimulatory signaling. Two transcript variantsencoding different isoforms have been found for this gene.
Other Names:
Integrin alpha-L, CD11 antigen-like family member A, Leukocyte adhesion glycoprotein LFA-1 alpha chain, LFA-1A, Leukocyte function-associated molecule 1 alpha chain, CD11a, ITGAL, CD11A
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13692c was selected from the Center region of ITGAL. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: ITGAL (HGNC:6148)
Gene ID: 3683
Primary Accession: P20701
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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