ITGAM polyclonal, anti-human, mouse, rat

Background:
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene.

Synonyms: CD11B, CR3A, MAC-1, MAC1A, MO1A, SLEB6

Cellular Location: Membrane Single-pass type I membrane protein

Immunogen:
Recombinant protein of human ITGAM

Gene Symbol: ITGAM

Gene ID: 3684

Swiss prot: P11215

Calculated MW: 127kDa

Recommended dilution:
WB 1:500-2000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.