ITGAV Polyclonal Antibody

Background:
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes.

Research Area: Cancer, Cardiovascular, Microbiology, Stem Cells

Synonyms:
antigen identified by monoclonal L230, CD 51, CD51, DKFZp686A08142, Integrin alpha five, integrin alpha V beta 3, Integrin alpha-5, integrin alpha-V, Integrin alpha-V light chain, integrin alphaVbeta3, integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51), ITAV, ITGAV, MSK 8, Msk8, Vitronectin receptor subunit alpha, VNRA, VTNR

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse Integrin alpha-V

Swissprot: P06756,P43406

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

Concentration: 470 μg/mL
Dilution: IHC 1:300-1:1000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.