ITGB3BP Polyclonal Antibody

Background:
This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants.

Research Area: Epigenetics and Nuclear Signaling, Signal Transduction

Synonyms:
Beta 3 endonexin, Beta3 endonexin, Beta3 endonexin long form, CENP R, CENPR, CENPR, Centromere protein R, endonexin, Beta-3, HSU37139, Integrin beta 3 binding protein (beta3-endonexin), Integrin beta 3 binding protein, NRIF 3, NRIF3, Nuclear receptor interacting factor 3, TAP 20, TAP20

Immunogen: Recombinant protein of human ITGB3BP

Swissprot: Q13352
Gene Accession: BC014385

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.7 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-69249/sc-69251