ITGB3BP Polyclonal Antibody

Background:
This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants.

Research Area: Epigenetics and Nuclear Signaling, Signal Transduction

Synonyms:
ITGB3BP, CENP-R, CENPR, HSU37139, NRIF3, TAP20

Immunogen: Recombinant fusion protein of human ITGB3BP (NP_055103.3).

Swissprot: Q13352
Gene ID: 23421

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.