ITGB7 Polyclonal Antibody

Background:
This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

Research Area: Cancer, Signal transduction, Stem cells

Synonyms:
Gut homing receptor beta subunit, Integrin beta 7 subunit, Integrin beta-7, Integrin beta-P, Integrin, beta 7, ITB7, ITB7, Itgb7, Ly69, M290 IEL antigen

Immunogen: Synthetic peptide of human ITGB7

Swissprot: P26010
Gene Accession: NP_000880

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.7 mg/mL
Dilution: IHC 1:100-1:300

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-6634/sc-6635/sc-15330