ITIH3 polyclonal, anti-human
€305.00
In stock
SKU
BS60741
Background:
The inter-α trypsin inhibitor (ITI) family is a group of structurally related plasma serine protease inhibitors synthesized in the liver and built up from different combinations of three highly homologous heavy chains (ITI-H1, ITI-H2 and ITI-H3) and one light chain (Bikunin). A fourth member of the ITI family, ITI-H4 (also known as I α IH4P) harbors a Pro-rich region (PRR) in its C-terminus. ITI is a glycoprotein composed of three polypeptides linked by chondroitin sulphate: two heavy chains, ITI-H1 and ITI-H2, and Bikunin. Bikunin confers the protease-inhibitor function of ITI. The heavy chains of the ITI family, designated as SHAPs (for serum-derived hyaluronan-associated proteins),bind covalently to hyaluronic acid (HA), resulting in pericellular matrix stabilization. Although ITI-H1, ITI-H3 and Bikunin have antitumoral and antimetastatic properties in the cell, these proteins are also associated with malignant transformation of lung tissue. ITI-H3 and Bikunin associate to form pre-α-trypsin inhibitor (PαI), a serine-proteinase inhibitor found in human serum.ITI-H3 mRNA levels increase in response to IL-6.
Alternative Name:
Inter-alpha-trypsin inhibitor heavy chain H3, ITI heavy chain H3, ITI-HC3, Inter-alpha-inhibitor heavy chain 3, Serum-derived hyaluronan-associated protein, SHAP, ITIH3
Application Dilution: WB: 1:500~1:1000
Specificity: ITIH3 polyclonal antibody detects endogenous levels of ITIH3 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human ITIH3
MW: ~ 100 kDa
Swis Prot.: Q06033
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The inter-α trypsin inhibitor (ITI) family is a group of structurally related plasma serine protease inhibitors synthesized in the liver and built up from different combinations of three highly homologous heavy chains (ITI-H1, ITI-H2 and ITI-H3) and one light chain (Bikunin). A fourth member of the ITI family, ITI-H4 (also known as I α IH4P) harbors a Pro-rich region (PRR) in its C-terminus. ITI is a glycoprotein composed of three polypeptides linked by chondroitin sulphate: two heavy chains, ITI-H1 and ITI-H2, and Bikunin. Bikunin confers the protease-inhibitor function of ITI. The heavy chains of the ITI family, designated as SHAPs (for serum-derived hyaluronan-associated proteins),bind covalently to hyaluronic acid (HA), resulting in pericellular matrix stabilization. Although ITI-H1, ITI-H3 and Bikunin have antitumoral and antimetastatic properties in the cell, these proteins are also associated with malignant transformation of lung tissue. ITI-H3 and Bikunin associate to form pre-α-trypsin inhibitor (PαI), a serine-proteinase inhibitor found in human serum.ITI-H3 mRNA levels increase in response to IL-6.
Alternative Name:
Inter-alpha-trypsin inhibitor heavy chain H3, ITI heavy chain H3, ITI-HC3, Inter-alpha-inhibitor heavy chain 3, Serum-derived hyaluronan-associated protein, SHAP, ITIH3
Application Dilution: WB: 1:500~1:1000
Specificity: ITIH3 polyclonal antibody detects endogenous levels of ITIH3 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human ITIH3
MW: ~ 100 kDa
Swis Prot.: Q06033
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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