ITM2B Antibody (C-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP13163b
Background:
Amyloid precursor proteins are processed by beta-secretaseand gamma-secretase to produce beta-amyloid peptides which form thecharacteristic plaques of Alzheimer disease. This gene encodes atransmembrane protein which is processed at the C-terminus by furinor furin-like proteases to produce a small secreted peptide whichinhibits the deposition of beta-amyloid. Mutations which result inextension of the C-terminal end of the encoded protein, therebyincreasing the size of the secreted peptide, are associated withtwo neurogenerative diseases, familial British dementia andfamilial Danish dementia.
Other Names:
Integral membrane protein 2B, Immature BRI2, imBRI2, Protein E25B, Transmembrane protein BRI, Bri, BRI2, membrane form, Mature BRI2, mBRI2, BRI2 intracellular domain, BRI2 ICD, BRI2C, soluble form, Bri23 peptide, Bri2-23, ABri23, C-terminal peptide, P23 peptide, ITM2B, BRI, BRI2
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13163b was selected from the C-term region of ITM2B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: ITM2B
Gene ID: 9445
Primary Accession: Q9Y287
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Amyloid precursor proteins are processed by beta-secretaseand gamma-secretase to produce beta-amyloid peptides which form thecharacteristic plaques of Alzheimer disease. This gene encodes atransmembrane protein which is processed at the C-terminus by furinor furin-like proteases to produce a small secreted peptide whichinhibits the deposition of beta-amyloid. Mutations which result inextension of the C-terminal end of the encoded protein, therebyincreasing the size of the secreted peptide, are associated withtwo neurogenerative diseases, familial British dementia andfamilial Danish dementia.
Other Names:
Integral membrane protein 2B, Immature BRI2, imBRI2, Protein E25B, Transmembrane protein BRI, Bri, BRI2, membrane form, Mature BRI2, mBRI2, BRI2 intracellular domain, BRI2 ICD, BRI2C, soluble form, Bri23 peptide, Bri2-23, ABri23, C-terminal peptide, P23 peptide, ITM2B, BRI, BRI2
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13163b was selected from the C-term region of ITM2B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: ITM2B
Gene ID: 9445
Primary Accession: Q9Y287
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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