ITM2B polyclonal, anti-human

Background:
Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. 

Synonyms: BRI, BRI2, BRICD2B, E25B, E3-16

Cellular Location: Cytoplasm Cell membrane

Immunogen:
Recombinant protein of human ITM2B

Gene Symbol: ITM2B

Gene ID: 9445

Swiss prot: Q9Y287

Calculated MW: 30kDa

Recommended dilution:
WB 1:5000-8000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.