ITM2B Polyclonal Antibody

Background:
Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.

Research Area: Neuroscience

Synonyms:
ABRI, ABri/ADan amyloid peptide, BRI 2, BRI, BRI2, BRICD 2B, BRICD2B, BRICHOS domain containing 2B, E25B, E3 16, E3-16, FBD, imBRI2, Immature BRI2, Integral membrane protein 2B, ITM 2B, ITM2B, ITM2B, Protein E25B, RDGCA, Transmembrane protein BRI

Immunogen: Fusion protein of human ITM2B

Swissprot: Q9Y287
Gene Accession: BC000554

Calculated MW: 30 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.2 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.